Bioorganic and Medicinal Chemistry Letters p. 3451 - 3455 (2004)
Update date:2022-08-04
Topics:
Lherbet, Christian
Gravel, Christian
Keillor, Jeffrey W.
A series of S-alkyl L-homocysteine analogues of glutathione was synthesized with varied oxidation state of the sulfur and tested for inhibition of rat kidney γ-glutamyl transpeptidase (GGT). The strong selectivity of the enzyme with respect to the sulfur oxidation state reveals important information for the development of powerful competitive inhibitors.
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