Journal of Pharmaceutical Sciences p. 622 - 626 (1993)
Update date:2022-08-04
Topics:
Baertschi
Dorman
Occolowitz
Spangle
Collins
Wildfeuer
Lorenz
The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by preparative high-performance liquid chromatography. Mechanistically, the formation of this degradent from cefaclor involves a condensation of two cefaclor degradation products in which both products have undergone contraction from a six-membered cephem ring to a five-membered thiazole ring, presumably via a common episulfonium ion intermediate.
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