Journal of Heterocyclic Chemistry p. 1355 - 1367 (1997)
Update date:2022-08-02
Topics:
Batty, Craig A.
Manthey, Michael K.
Kirk, Julie
Manthey, Monika
Christopherson, Richard I.
Hambley, Trevor
An improved preparation of 2-oxo-6-thioxo-1,2,3,6-hexahydropyrimidine-4-carboxylic acid 3, a potent inhibitor of dihydroorotase is presented. Trans-5-alkyl-2-oxo-6-thioxohexahydropyrimidine-4-carboxylic acids 12a-c were synthesised via the thiation of the
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