Preparation and biological actions of N-2,2,2-trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine

Article abstract of DOI:10.1002/jps.2600690208

N-2,2,2-Trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine was synthesized and compared to N-ethyl-2-(3,4-dihydroxyphenyl)-ethylamine and dopamine for activity on adenylate cyclase in the rat striatum. Both dopamine and N-ethyl-2-(3,4-dihydroxyphenyl)ethyl-amine stimulated adenylate cyclase activity in a dose-dependent fashion. The N-trifluorethyldopamine analog at 1 x 10^-4 M induced a weak effect. The compounds were evaluated further by studying their relaxant effects in isolated rabbit renal and ear arteries. Both the N-ethyl- and N-trifluoroethyldopamine analogs produced a relaxant effect but demonstrated no selectivity for dopamine receptors.