Bioorganic and Medicinal Chemistry Letters p. 2411 - 2415 (2006)
Update date:2022-08-04
Topics:
Das, Jagabandhu
Liu, Chunjian
Moquin, Robert V.
Lin, James
Furch, Joseph A.
Spergel, Steven H.
McIntyre, Kim W.
Shuster, David J.
O'Day, Kathleen D.
Penhallow, Becky
Hung, Chen-Yi
Kanner, Steven B.
Lin, Tai-An
Dodd, John H.
Barrish, Joel C.
Wityak, John
A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 2 i
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