Resolution of trans-1,2-Dihydroxy-1,2-dihydrobenzene for the Preparation of Optically Pure Benzene Diol Epoxides. Preparation of Bromo- and Chlorobenzene Diol Epoxides

Article abstract of DOI:10.1021/jo00273a005

The resolution of (+/-)-trans-1,2-dihydroxy-1,2-dihydrobenzene <(+/-)-2> has been accomplished by esterase-catalysed hydrolysis of diacetate (+/-)-5.Peracid epoxidation of (+)-2 and (-)-2 gave diol epoxides (+)-3 and (-)-3, respectively.The synthesis of d