Chemistry, Pharmacology, and Structure-Activity Relationships with a New Type of Imidazolines Exerting a Specific Bradycardic Action at a Cardiac Site

Article abstract of DOI:10.1021/jm00185a013

The reaction of alkyl halides with 2-(arylimino)imidazolidines (I) leads to imidazoline derivatives II, in which the side chain is situated at the bridge nitrogen atom between the phenyl group and the imidazoline ring.The new imidazolines (II) exert a spe