Synthetic and preliminary hemodynamic and whole animal toxicity studies on (R, S)-, (R)-, and (S)-2-methyl-3-(2,4,5-trihydroxyphenyl)alanine

DOI: 10.1021/jm00186a007

Source and publish data:

Journal of Medicinal Chemistry p. 1318 - 1323 (1980)

Update date:2022-07-30

Topics:

Authors:

Musson Musson

Karashima

Rubiero Rubiero

Melmon Melmon

Cheng Cheng

Castagnoli Jr.

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Article abstract of DOI:10.1021/jm00186a007

The synthesis, resolution, and absolute configuration assignment of 2-methyl-3-(2,4,5-trihydroxyphenyl)alanine (6-OH-α-Me-Dopa) are reported. Hemodynamic studies in the rat have shown that this structural analogue and potential metabolite of the clinicall

Full text of DOI:10.1021/jm00186a007

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