Reaction of α-Azido Esters with Lithium Ethoxide: Synthesis of Dehydroamino Esters and α-Keto Esters

DOI: 10.1021/jo01312a025

Source and publish data:

Journal of Organic Chemistry p. 4952 - 4954 (1980)

Update date:2022-08-04

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Authors:

Manis, Paul A.

Rathke, Michael W.

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Article abstract of DOI:10.1021/jo01312a025

α-Azido esters 4 react with catalytic amounts of ethoxide in tetrahydrofuran/ethanol to evolve nitrogen and form dehydroamino esters 3.Acid hydrolysis gives α-keto esters 5 in good yields.

Full text of DOI:10.1021/jo01312a025

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