Chemical and Pharmaceutical Bulletin p. 1181 - 1187 (1996)
Update date:2022-07-30
Topics:
Lien, Jin-Cherng
Huang, Li-Jiau
Wang, Jih-Pyang
Teng, Che-Ming
Lee, Kuo-Hsiung
Kuo, Sheng-Chu
Modification of 2-acetamido-3-chloro-1,4-naphthoquinone, which has potent antiplatelet, antiallergic and antiinflammatory activities, led to a series of 2,3-disubstituted 1,4-naphthoquinones. Some of these compounds showed significant antiplatelet, antiallergic and antiinflammatory activities. Among them, 2-methoxy-3-chloro-1,4-naphthoquinone (15) and 2- ethoxy-3-chloro-1,4-naphthoquinone (17) exhibited potent inhibitory effects on neutrophil and mast cell degranulation. 2-Methoxy-1,4-naphthoquinone (20) and 2-ethoxy-1,4-naphthoquinone (21) exhibited potent inhibitory effect on neutrophil superoxide formation. These four compounds were thus selected for further evaluation.
View MoreA.M FOOD CHEMICAL CO., LIMITED
Contact:86-531-87100375
Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
zhangjiagang bonded areas banggao co;ltd
website:http://www.shunchangchem.com
Contact:0086-13921972933
Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Dalian RSD International Trade Co.,Ltd.(expird)
Contact:86-22-60875058 58610575
Address:Wantong International Areas, Hongqiao District, Tianjin, China.China
Contact:27-792-602929
Address:SIDNEY MUFAMADI STREET 009949 X44 0700 POLOKWANE,LIMPOPO
Xi'an North Information Industry Co., Ltd. Weilv Chemical Department
Contact:+86-29-88156413
Address:Jixiang Road 99 Xi'an Shaanxi Province
Doi:10.1039/P29840000095
(1984)Doi:10.1016/j.molstruc.2011.07.060
(2011)Doi:10.1016/j.jorganchem.2004.04.040
(2004)Doi:10.1021/jm040048d
(2004)Doi:10.1021/acs.orglett.9b00735
(2019)Doi:10.1039/P19800001194
(1980)
