Chemical and Pharmaceutical Bulletin p. 1181 - 1187 (1996)
Update date:2022-07-30
Topics:
Lien, Jin-Cherng
Huang, Li-Jiau
Wang, Jih-Pyang
Teng, Che-Ming
Lee, Kuo-Hsiung
Kuo, Sheng-Chu
Modification of 2-acetamido-3-chloro-1,4-naphthoquinone, which has potent antiplatelet, antiallergic and antiinflammatory activities, led to a series of 2,3-disubstituted 1,4-naphthoquinones. Some of these compounds showed significant antiplatelet, antiallergic and antiinflammatory activities. Among them, 2-methoxy-3-chloro-1,4-naphthoquinone (15) and 2- ethoxy-3-chloro-1,4-naphthoquinone (17) exhibited potent inhibitory effects on neutrophil and mast cell degranulation. 2-Methoxy-1,4-naphthoquinone (20) and 2-ethoxy-1,4-naphthoquinone (21) exhibited potent inhibitory effect on neutrophil superoxide formation. These four compounds were thus selected for further evaluation.
View MoreContact:
Address:
Suzhou Credit International Trading Co., Ltd
Contact:+86-512-65398039
Address:Qingdeng, Hightech. District, Suzhou
Contact:+852 83038667
Address:Room 1502, 15th Floor, SPA Centre,53-55 Lockhart Road, Wanchai, Hong Kong
CHANGYI CITY FENGRUN FINE CHEMICAL CO.,LTD
website:http://www.fengrunhuagong.com
Contact:+86-536-7869976
Address:Changyi Coastal Economic Development Zone
Contact:+91 - 22 - 26355700
Address:17, Lotus Business Park, Andheri West
Doi:10.1039/P29840000095
(1984)Doi:10.1016/j.molstruc.2011.07.060
(2011)Doi:10.1016/j.jorganchem.2004.04.040
(2004)Doi:10.1021/jm040048d
(2004)Doi:10.1021/acs.orglett.9b00735
(2019)Doi:10.1039/P19800001194
(1980)
