Bioorganic and Medicinal Chemistry Letters p. 4131 - 4134 (2004)
Update date:2022-08-02
Topics: Design and Synthesis
Kurihara, Masaaki
Shamsur Rouf, Abu Shara
Kansui, Hisao
Kagechika, Hiroyuki
Okuda, Haruhiro
Miyata, Naoki
Retinoids are natural and synthetic analogues of all-trans retinoic acid (ATRA). Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids. We report here the design and synthesis of novel cyclic urea compounds with retinoidal activity. YR105 exhibited potent differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells at the concentration of 10-9M: its potency was almost equal to that of the native ligand, all-trans retinoic acid.
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