Synthesis of 1,3-Diazepin-2-one Nucleosides as Transition-State Inhibitors of Cytidine Deaminase. 2

Article abstract of DOI:10.1021/jo01313a049

Syntheses of the novel seven-membered-ring (+-)-5-hydroxy-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-one (8) and its 1-β-D-ribofuranosyl nucleosides 4a and 4b have been accomplished by adaption of the transpositional allylic oxidation procedure following the electrophilic addition of ArSeOH to the corresponding starting olefins 5 and 11.