Journal of Medicinal Chemistry p. 1452 - 1457 (1984)
Update date:2022-07-30
Topics:
Buckle, Derek R.
Outred, D. James
Smith, Harry
Spicer, Barbara A.
In a small range finding study a number of N-benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin have been shown to combine potent H1-antihistamine activity with that of mast cell stabilization as demonstrated by their activity as antagonists of histamine on guinea pig ileum and by their inhibition of the release of histamine in rat passive peritoneal anaphylaxis (PPA).The most potent compound, 1-<2-hydroxy-3-<(4-hydroxy-3-nitrocoumarin-7-yl)oxy>propyl>-4-(4-chlorobenzyl)piperazine, 30, had a pA2 of 9.0 against histamine on guinea pig ileum and inhibited histamine release in the rat PPA test with a potency similar to that of disodium cromoglycate.
View MoreHebei Fulong Import & Export Co., Ltd.
Contact:86-311-87795661
Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
Changzhou LanXu Chemical Co.,ltd.(expird)
Contact:86-0519-86330911,13656129734,15261186386
Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
Contact:+91 - 22 - 26355700
Address:17, Lotus Business Park, Andheri West
Hunan Zhongqi Pharmaceutical Co., Ltd
website:http://www.hnzqzy.com
Contact:0730-8722288 13807308622
Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Jurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Doi:10.1021/ic50220a001
(1981)Doi:10.1021/jo00392a011
(1987)Doi:10.1021/jo00318a024
(1981)Doi:10.1021/jo01170a023
(1947)Doi:10.1021/ja00176a006
(1990)Doi:10.1016/S0020-1693(00)93386-3
(1979)
