
Journal of the Chemical Society. Perkin transactions I p. 1928 - 1932 (1980)
Update date:2022-08-05
Topics:
Allen, Mark C.
Brundish, Derek E.
Wade, Roy
The synthesis of 5- and 7-bromo-L-tryptophans via Fischer cyclisation of the appropriate bromophenylhydrazone of 4-acetamido-4,4-bis(ethoxycarbonyl)butanal is described.The title tetracosapeptide was synthesised using standard methods of stepwise and fragment condensation.The product was pure as judged by amino-acid analysis after acidic or enzymic hydrolysis and by high pressure liquid chromatography.In an isolated adrenal cell bioassay, the peptide had a steroidogenic potency 2.4 times that of Synacthen.
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Doi:10.1246/bcsj.54.985
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