Chemical and pharmaceutical bulletin p. 676 - 680 (1990)
Update date:2022-09-26
Topics:
Yoshino
Goto
Kohno
Morita
Tsukamoto
Various asymmetric or cyclic ester derivatives of the phosphonic acid moiety in the calcium antagonist fostedil (KB-944) were synthesized. The coronary vasodilator activity of these compounds was assessed by Langendorff's method. Among them, the ethyl isopropyl ester 12 showed the most potent activity, which was comparable to that of fostedil.
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