Organic phosphorus compounds. IV. Asymmetric 4-(benzothiazol-2-yl)benzylphosphonates as potent calcium antagonistic vasodilators.

DOI: 10.1248/cpb.38.676

Source and publish data:

Chemical and pharmaceutical bulletin p. 676 - 680 (1990)

Update date:2022-09-26

Topics:

Authors:

Yoshino Yoshino

Goto Goto

Kohno Kohno

Morita Morita

Tsukamoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.38.676

Various asymmetric or cyclic ester derivatives of the phosphonic acid moiety in the calcium antagonist fostedil (KB-944) were synthesized. The coronary vasodilator activity of these compounds was assessed by Langendorff's method. Among them, the ethyl isopropyl ester 12 showed the most potent activity, which was comparable to that of fostedil.

Full text of DOI:10.1248/cpb.38.676

NII-Electronic Library Service

Products guided by the article

Product name:4-(Benzothiazol-2-yl)benzylphosphonic Acid 2,4-Pentanediol Cyclic Ester

Cas No:75925-97-2

R&D Labs maybe for 75925-97-2

Shanghai Puda Chemical Co.,Ltd

Contact:+86+571+56565965

Address:10F Haiyue Building,Danfeng Road,Binjiang District,Hangzhou,China
Deer Chemicals Co., Ltd.

Contact:+86-13666670345

Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
Shijiazhuang Frontierchem Co., Ltd.

Contact:+86-311-89271196

Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Rugao Jinling Chemical Co., Ltd.(expird)

Contact:0086-513-68005586

Address:Lianluo new village huangshi town Rugao city Jiangsu Province.
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou

Relevant to this article

Regioselective synthesis of 1-aklyl-4-(3-pyridyl)-substituted imidazole

Doi:10.1021/op0498767
(2004)
ORGANOMETALLIC COMPOUNDS. LXXI. SYNTHESIS AND PROPERTIES OF ALDEHYDIC AND KETONIC TETRAORGANOTIN COMPOUNDS

Doi:10.1016/S0022-328X(00)86629-2
(1981)
METALLATION REGIOSELECTIVE EN SERIE PYRIDINIQUE: SYNTHESE ORIGINALE D'AMINO-2-AROYL 3-PYRIDINES

Doi:10.1016/S0022-328X(00)80124-2
(1981)
Doi:10.1021/ja00365a043
(1982)
Catalytic unfolding and proteolysis of cytochrome c induced by synthetic binding agents

Doi:10.1021/ja0317731
(2004)
Synthetic Applications of Conjugated Azocarbinols. Radical Chain Hydrophenylation and Hydrocyclohexenylation of Haloethenes

Doi:10.1021/ja00414a025
(1981)

Article Doi