Ethyl 3-Aryl-3-hydroxy-2,2-dimethylpropionates and 6-Aryl-3,3,5,5-tetramethyltetrahydropyran-2,4-diones

Article abstract of DOI:10.1002/ardp.19803130912

The chloroketones 1 react with equimolar amounts of a 10percent solution of sodium hydroxide in acetone to give the hydroxyketones 2.They were to be transformed into the substituted ethyl propionates 5 which are similar to clofibrate.As this synthesis fai