IMINOHEPTITOLS AS GLYCOSIDASE INHIBITORS: SYNTHESIS OF, AND MANNOSIDASE AND FUCOSIDASE INHIBITION BY, Α-HOMOMANNOJIRIMYCIN AND 6-EPI-HOMOMANNOJIRIMYCIN

Article abstract of DOI:10.1016/S0040-4039(01)93952-8

C-2 and C-6 of a heptonolactone are joined together by nitrogen to afford α-homomannojirimycin (HMJ) and 6-epi-α-homomannojirimycin; the inhibition of some α-mannosidases and α-fucosidases by these iminoheptitols is reported.