Journal of the Chemical Society. Perkin transactions I p. 1725 - 1730 (1985)
Update date:2022-08-03
Topics:
Bromidge, Steven M.
Sammes, Peter G.
Street, Leslie J.
A route to the sesquiterpene (+/-)-β-bulnesene is described which starts with the substituted furan, 2-(1-hydroxy-4-methylhex-5-enyl)furan.Oxidation of the latter generates a precusor of a 2-substituted 3-oxidopyrylium, which undergoes smooth intramolecular cyclisation to generate a highly functionalised perhydroazulene intermediate.Further chemical manipulation of the latter readily generates the desired natural product.In order to control the relative geometry of the pendent-4-methyl group in the target molecule, a method involving the stereoselective reduction of an exocyclic methylene group is employed; the means for introducing such methylene groups are detailed.
View MoreXinji City Taida Sinopec Co., Ltd.
Contact:0086-311-85341278
Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
Shenzhen HwaGen Pharmaceutical Co., Ltd
website:http://www.rafflespt.com
Contact:+86-752-5538396
Address:Guangdong Huizhou China
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd
Contact:+86 411 84674606
Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Yixing Bluwat Chemicals Co., Ltd.
Contact:+86 510 87821568
Address:Yongan Road, Yixing Chemical Industrial Park, Yixing, Jiangsu, China
Shandong Yuanli Science and Technology Co., Ltd.
Contact:86-0536-6777557
Address:Zhuliu Industiral Park,Changle County
Doi:10.1039/c29710000542
(1971)Doi:10.1039/c7ra09995a
(2017)Doi:10.1016/j.tet.2004.06.043
(2004)Doi:10.1248/cpb.28.2819
(1980)Doi:10.1002/jhet.5570200313
(1983)Doi:10.1016/0040-4020(80)80105-0
(1980)
