6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation

DOI: 10.1016/S0960-894X(99)00411-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2469 - 2472 (1999)

Update date:2022-07-29

Topics:

Authors:

Ryu, Chung-Kyu

Jung, Sung-Hee

Lee, Joung-Ah

Kim, Hwa-Jung

Lee, Soo-Hwan

Chung, Jin-Ho

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Article abstract of DOI:10.1016/S0960-894X(99)00411-4

6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b

Full text of DOI:10.1016/S0960-894X(99)00411-4

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