SYNTHESIS OF SOME BENZIMIDAZOLES CONTAINING 2-PERFLUORO SUBSTITUENTS

Article abstract of DOI:10.1016/S0022-1139(00)82615-9

A new method is described for the preparation of 2-perfluoroalkylether-benzimidazoles through the N-monoacyl derivatives of o-phenylenediamine. 2-Pentafluorophenylbenzimidazole has been obtained by the reaction of o-phenylenediamine and pentafluorobenzoic acid in the presence of polyphosphoric acid. 2-Perfluoroalkylbenzimidazoles have been prepared in excellent yields by direct condensation of o-phenylenediamine with perfluoroalkane-carboxylic acids in the absence of any solvent or added reagent.Some derivatives of these compounds are also described.