Tetrahedron p. 1791 - 1799 (1980)
Update date:2022-08-02
Topics:
Rudorf, W.-D.
The ketene S,S-acetals 1 readily react with aziridine to give the corresponding 3-(1-aziridinyl)-3-methylthio-acrylnitriles 2 and 3,3-bis-(1-aziridinyl)-acrylnitriles 3.Ketene S,N-acetals 4 yield 3-anilino-3-(1-aziridinyl)-acrylnitriles 5.Reaction of 5 with potassium iodide in acetone at room temperature leads to imidazolidines 8.The isomerisation is explained in terms of a two-step mechanism.The iodide ion-catalysed rearrangement was not successful when applied to 2a.Cyclisation of 5b in the presence of sodium hydride and following hydrolysis form the tautomeric quinolone 10.On contrary to 1 and 4 mercapto ethylenes 11 and 13 with aziridine give the thiazolidine 15.
View MoreContact:86-574-26865651
Address:529 YuanBaoShan Road, Beilun District
Jiaxing Anrui Material Technology Co., Ltd.
Contact:86-573-82651652 13305832579
Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
Shaanxi HuaTai Bio-fine chemical company Ltd
Contact:86-029-87862197
Address:No. 5, 3rd Floor, 29 Yanta North Road, Beilin Dist.
Contact:86-551-63540590
Address:No 1388 Furong Rd., Hefei, Anhui, China
Airsea(Taizhou) Pharmaceutical Limited(expird)
Contact:+86-576-88057622
Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Doi:10.1007/s11172-006-0495-5
(2006)Doi:10.1246/bcsj.71.2669
(1998)Doi:10.1016/S0040-4039(01)90556-8
(1981)Doi:10.1055/s-2004-829076
(2004)Doi:10.1021/jo00932a011
(1974)Doi:10.1021/ja046586x
(2004)
