SYNTHESIS OF 6-SUBSTITUTED URIDINES. SYNTHESIS OF (R OR S)-6-(3-AMINO-2-CARBOXYPROPYL)URIDINE

Article abstract of DOI:10.1016/S0008-6215(00)84560-7

Addition of 5-bromo-2',3'-O-isopropylidene-5'-O-trityluridine (2) in pyridine to an excess of 2-lithio-1,3-dithiane (3) in oxolane at -78 degC gave (6R)-5,6-dihydro-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine (4), (5S,6S)-5-bromo-5,6-dihy