(2S,3S,4R)-4-Amino-3-hydroxy-2-methylvalerate. Synthesis of an amino acid constituent of bleomycin form L-rhamnose

Article abstract of DOI:10.1021/jo00319a046

(2S,3S,4R)-4-Amino-3-hydroxy-2-methylvalerate, an amino acide constituent of the antitumor antibiotic bleomycin, has been prepared from L-rhamnose.This approach to achiral 3-hydroxy-2-methylcarboxylate constitutes an alternative to the stereoselective ald