Intramolecular 1,1-Cycloaddition of Nitrilimines as a Route to Benzodiazepines and Cyclopropacinnolines

DOI: 10.1021/jo00320a035

Source and publish data:

Journal of Organic Chemistry p. 1402 - 1409 (1981)

Update date:2022-08-02

Topics:

Authors:

Padwa, Albert

Nahm, Steven

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00320a035

Treatment of o-vinylphenyl-substituted chloroglyoxylate phenylhydrazones with base leads to nitrilimines.These reactive 1,3-dipoles undergo intramolecular 1,1-cycloaddition with complete retention of configuration to give cyclopropacinnolines.When the

Full text of DOI:10.1021/jo00320a035

Products guided by the article

Product name:ethyl 2-chloro-2-<(o-vinylphenyl)azo>acetoacetate

Cas No:76466-73-4

R&D Labs maybe for 76466-73-4

Sinoway Industrial Co., Ltd.

website:http://www.china-sinoway.com

Contact:+86-592-5853819

Address:16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China
Shanghai Norky Pharmaceutical Co., LTD.

website:http://www.norkypharm.com

Contact:86-21-61075300

Address:1165 Jiangning Road, Office 1502, Shanghai, China
Dezhou Longteng Chemical Co., Ltd.

website:http://www.sodium-methoxide.cn/

Contact:0086-18866052283

Address:Xinhua Industrial Zone, Dezhou City, Shandong Province, China
Hebei Maison Chemical Co.,Ltd

website:http://www.maisonchem.com.cn

Contact:0086-311-83833777

Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Taizhou Shengxing Chempharm Co.,Ltd

Contact:+86-576-88516600

Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China

Relevant to this article

Conceptualization and Synthesis of the First Inosito-Inositol (Decahydroxydecalin, DHD): In silico Binding to β-Amyloid Protein

Doi:10.1002/chem.202003367
(2020)
Facile and catalytic degradation method of DDT using Pd/C-Et₃N system under ambient pressure and temperature

Doi:10.1016/j.tet.2006.06.041
(2006)
BORON ANNULATION: TOTAL SYNTHESIS OF (+/-)-ESTRONE METHYL ETHER

Doi:10.1016/S0040-4039(00)93155-1
(1980)
Vinyl-copper derivatives-XI¹ 1 Part X: A. Alexakis, G. Cahiez and J.F. Normant, Synthesis, 826 (1979). Reactivity of Z-alkenyl cuprates towards various electrophiles. Application to the synthesis of some natural products

Doi:10.1016/0040-4020(80)80209-2
(1980)
Synthesis of 2,2-Dichloro-1,3-diarylaziridines by Reduction of Trichloroacetophenone Imines

Doi:10.1021/jo00323a020
(1981)
Spectroscopic and Electrochemical Investigations into the Interactions of Metal Ions with a Ferrocenoyl-Histidine Peptide Conjugate

Doi:10.1002/ejic.201000658
(2010)

Article Doi