Intramolecular 1,1-Cycloaddition of Nitrilimines as a Route to Benzodiazepines and Cyclopropacinnolines

DOI: 10.1021/jo00320a035

Source and publish data:

Journal of Organic Chemistry p. 1402 - 1409 (1981)

Update date:2022-08-02

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Authors:

Padwa, Albert

Nahm, Steven

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Article abstract of DOI:10.1021/jo00320a035

Treatment of o-vinylphenyl-substituted chloroglyoxylate phenylhydrazones with base leads to nitrilimines.These reactive 1,3-dipoles undergo intramolecular 1,1-cycloaddition with complete retention of configuration to give cyclopropacinnolines.When the

Full text of DOI:10.1021/jo00320a035

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