Intramolecular 1,1-Cycloaddition of Nitrilimines as a Route to Benzodiazepines and Cyclopropacinnolines

DOI: 10.1021/jo00320a035

Source and publish data:

Journal of Organic Chemistry p. 1402 - 1409 (1981)

Update date:2022-08-02

Topics:

Authors:

Padwa, Albert

Nahm, Steven

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00320a035

Treatment of o-vinylphenyl-substituted chloroglyoxylate phenylhydrazones with base leads to nitrilimines.These reactive 1,3-dipoles undergo intramolecular 1,1-cycloaddition with complete retention of configuration to give cyclopropacinnolines.When the

Full text of DOI:10.1021/jo00320a035

Products guided by the article

Product name:ethyl 2-chloro-2-<(o-vinylphenyl)azo>acetoacetate

Cas No:76466-73-4

R&D Labs maybe for 76466-73-4

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

website:http://www.czyys.com

Contact:0086-519-88802789

Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China
Taimai Sanluck Pharmaceutical Co.,Ltd

Contact:86-592-7662921

Address:8D,No.186,Huarong Road,Huli,Xiamen,China
Yancheng Smiling Imp & Exp Co., Ltd.

Contact:+86-515-83173586

Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Lyan Limited

Contact:86-021-52418058

Address:8/F, Building 6, Guiping Road No.333, Shanghai, 200233, China
Shanghai Haoyuan Chemexpress Co., Ltd.

website:https://www.chemexpress.com/

Contact:86-21-58950125

Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203

Relevant to this article

Conceptualization and Synthesis of the First Inosito-Inositol (Decahydroxydecalin, DHD): In silico Binding to β-Amyloid Protein

Doi:10.1002/chem.202003367
(2020)
Facile and catalytic degradation method of DDT using Pd/C-Et₃N system under ambient pressure and temperature

Doi:10.1016/j.tet.2006.06.041
(2006)
BORON ANNULATION: TOTAL SYNTHESIS OF (+/-)-ESTRONE METHYL ETHER

Doi:10.1016/S0040-4039(00)93155-1
(1980)
Vinyl-copper derivatives-XI¹ 1 Part X: A. Alexakis, G. Cahiez and J.F. Normant, Synthesis, 826 (1979). Reactivity of Z-alkenyl cuprates towards various electrophiles. Application to the synthesis of some natural products

Doi:10.1016/0040-4020(80)80209-2
(1980)
Synthesis of 2,2-Dichloro-1,3-diarylaziridines by Reduction of Trichloroacetophenone Imines

Doi:10.1021/jo00323a020
(1981)
Spectroscopic and Electrochemical Investigations into the Interactions of Metal Ions with a Ferrocenoyl-Histidine Peptide Conjugate

Doi:10.1002/ejic.201000658
(2010)

Article Doi