Journal of the Chemical Society. Perkin transactions I p. 2755 - 2761 (1980)
Update date:2022-08-04
Topics:
Kobayashi, Yoshiro
Yamamoto, Kenjiro
Asai, Toyohira
Nakano, Masanori
Kumadaki, Itsumaro
Halogenated nucleoside derivatives were trifluoromethylated using a solution of a trifluoromethyl-copper complex, which was prepared by shaking trifluoromethyl iodide and copper powder in hexamethylphosphoric triamide and filtering off the excess of copper powder.The following trifluoromethylated nucleosides were obtained in moderate to good yields: 5-trifluoromethyl-uridine, -deoxyuridine, -cytidine, -deoxycytidine, and arabinosylcytosine; 8-trifluoromethyl-adenosine, -deoxyadenosine, and -inosine; and 6-trifluoromethylribofuranosylpurine.This procedure offers simple synthesis of many trifluoromethyl compounds.
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