Novel tetrahydro-thieno pyridyl oxazolidinone: An antibacterial agent

Article abstract of DOI:10.1016/j.bmc.2004.07.019

We have synthesized and evaluated antibacterial activity of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones against several Gram-positive pathogens. Effect of various substituents on 5-position of the oxazolidinone ring has been studied. Synthesis of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones have been reported. They have been screened against a panel of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. A SAR has been developed. Compound 15 showed comparable activity (MIC) to linezolid and superior to eperezolid.