Heterocyclic Communications p. 403 - 406 (2005)
Update date:2022-08-04
Topics:
Koever, Jozsef
Tompa, Jozsef
Antus, Sandor
Gunda, Tamas
An efficient synthesis of (R)-(+)-2-[4-(6-chloro-2-quinoxalinyloxy)- phenoxy]-propion-amide 4a-e is described by simple amidation of Quizalofop-methyl [(R)-(+)-3]. The reduced susceptibility of quinoxalinyl moiety of (R)-(+)-3 toward nucleophilic reagents was discussed on the basis of QM calculation.
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