Chemistry of Natural Compounds p. 216 - 217 (1988)
Update date:2022-08-03
Topics:
Sorochinskaya, E. I.
Leont'eva, L. I.
Martynov, V. F.
Four different schemes for the synthesis by the classical method of pyroglutamylasparaginylglycine - a suggested aggression peptide have been described.The best is a scheme using C- and N-terminal protective groups of the benzyl type at the stage of obtaining the protected tripeptide.Literature information according to which the compound possesses biological activity has been refuted.
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Doi:10.1021/jo00180a038
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