Bioorganic and Medicinal Chemistry Letters p. 2001 - 2004 (2000)
Update date:2022-08-05
Topics:
Dauban, Philippe
Ferry, Sandrine
Faure, Hélène
Ruat, Martial
Dodd, Robert H.
The synthesis and calcimimetic properties of N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 μM) produced 974±11% of the maximal stimulation of [3H]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Science Ltd.
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