Pyridopyrimidines. 12. Synthesis of 8-deaza analogues of aminopterin and folic acid

DOI: 10.1021/jo00322a004

Source and publish data:

Journal of Organic Chemistry p. 1777 - 1781 (1981)

Update date:2022-08-02

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Authors:

Srinivasan, Ananthachari

Broom, Arthur D.

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Article abstract of DOI:10.1021/jo00322a004

A new, general approach to the synthesis of numerous 8-deazafolate and 8-deazaaminopterin analogues is described. The key intermediate, 6-(acetoxymethyl)-2,4-dichloropyrido[3,2-d]pyrimidine, was prepared by chlorination of the 2,4-dioxo derivative which,

Full text of DOI:10.1021/jo00322a004

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