Pyridopyrimidines. 12. Synthesis of 8-deaza analogues of aminopterin and folic acid

Article abstract of DOI:10.1021/jo00322a004

A new, general approach to the synthesis of numerous 8-deazafolate and 8-deazaaminopterin analogues is described. The key intermediate, 6-(acetoxymethyl)-2,4-dichloropyrido[3,2-d]pyrimidine, was prepared by chlorination of the 2,4-dioxo derivative which,