Journal of Organic Chemistry p. 1777 - 1781 (1981)
Update date:2022-08-02
Topics:
Srinivasan, Ananthachari
Broom, Arthur D.
A new, general approach to the synthesis of numerous 8-deazafolate and 8-deazaaminopterin analogues is described. The key intermediate, 6-(acetoxymethyl)-2,4-dichloropyrido[3,2-d]pyrimidine, was prepared by chlorination of the 2,4-dioxo derivative which,
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