Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates

DOI: 10.1002/jps.2600691034

Source and publish data:

Journal of Pharmaceutical Sciences p. 1232 - 1234 (1980)

Update date:2022-09-26

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Authors:

Roehrig Roehrig

Billman Billman

Marcec Marcec

Fritz Fritz

Shea Shea

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Article abstract of DOI:10.1002/jps.2600691034

Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.

Full text of DOI:10.1002/jps.2600691034

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Product name:butyl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate

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