Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates

DOI: 10.1002/jps.2600691034

Source and publish data:

Journal of Pharmaceutical Sciences p. 1232 - 1234 (1980)

Update date:2022-09-26

Topics:

Authors:

Roehrig Roehrig

Billman Billman

Marcec Marcec

Fritz Fritz

Shea Shea

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/jps.2600691034

Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.

Full text of DOI:10.1002/jps.2600691034

Products guided by the article

Product name:butyl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate

Cas No:77063-17-3

R&D Labs maybe for 77063-17-3

Jiangxi Biochem Co.,Ltd

Contact:86-791-86629460

Address:1-6F, 118 Xinzhou road, Nanchang, Jiangxi, China
Chengdu NoVi Biotechnology Co., Ltd.(expird)

Contact:13551243286/028-81458053

Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Onlychem (Jinan)Biotech Co.,Ltd

Contact:86-531-83175885

Address:No. 44, Honglou South Road, Jinan,China
Chengdu Green Young Biopharmaceutical INC

Contact:+86-28-85337952

Address:1-B-26,Tianhe Industry Park, No.1480 of Tianfu Road,Chengdu,P.R.China,610000
Zhejiang Kente Chemical Co.,Ltd.

Contact:86-0576-87651912

Address:No.7, Fengxi West Road, Modern Industrial Zone

Relevant to this article

In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model

Doi:10.1016/j.bmc.2013.09.011
(2013)
Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis

Doi:10.1039/c6cc09794d
(2017)
SYNTHESIS OF FORMAMIDINES FROM 2-AMINO-3-METHYLQUINAZOLIN-4-ONE AND ITS 6-NITRO DERIVATIVE

Doi:10.1007/BF00571048
(1980)
Me₂AlCl-mediated carboxylation, ethoxycarbonylation, and carbamoylation of indoles

Doi:10.1016/j.tet.2015.12.028
(2016)
Syntheses of N-(1-methyl-2-piperazinoethyl)propionanilides and 2-alkoxy-6-[N-[1-methyl-2-(4-phenethylpiperazino)ethyl]-propionamide]benzathiazoles

Doi:10.1248/cpb.28.3315
(1980)
Quinazolines and 1,4-benzodiazepines. XC(1). 2-aminoimidazo[1,5 a][1,4]benzodiazepin-1-ones and derivatives

Doi:10.1002/jhet.5570170810
(1980)

Article Doi