Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates

DOI: 10.1002/jps.2600691034

Source and publish data:

Journal of Pharmaceutical Sciences p. 1232 - 1234 (1980)

Update date:2022-09-26

Topics:

Authors:

Roehrig Roehrig

Billman Billman

Marcec Marcec

Fritz Fritz

Shea Shea

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/jps.2600691034

Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.

Full text of DOI:10.1002/jps.2600691034

Products guided by the article

Product name:butyl 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoate

Cas No:77063-17-3

R&D Labs maybe for 77063-17-3

Xinjiang Fufeng Biotechnologies Co., Ltd.

Contact:+86-539-7287111

Address:GANQUANPU INDUSTRIAL PARK, ECONOMIC AND TECHNOLOGICAL DEVELOPMENT AREA (TOUTUNHE DISTRICT) OF URUMQI
SHANDONG ZHANHUA YONGHAO PHARMACEUTICAL TECH.CO.,LTD

Contact:+86-576-88685096

Address:GENGJU VILLAGE NORTH ONE KILOMETER,ZHANHUA DISTRICT,BINZHOU CITY,SHANDONG PROVINCE,CHINA.
Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
Nantong LiKai Chemical Co.,Ltd

Contact:+86-513-89068669

Address:Jincheng Science Park
uni source industries limited

Contact:86 21 3772 9386

Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China

Relevant to this article

In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model

Doi:10.1016/j.bmc.2013.09.011
(2013)
Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysis

Doi:10.1039/c6cc09794d
(2017)
SYNTHESIS OF FORMAMIDINES FROM 2-AMINO-3-METHYLQUINAZOLIN-4-ONE AND ITS 6-NITRO DERIVATIVE

Doi:10.1007/BF00571048
(1980)
Me₂AlCl-mediated carboxylation, ethoxycarbonylation, and carbamoylation of indoles

Doi:10.1016/j.tet.2015.12.028
(2016)
Syntheses of N-(1-methyl-2-piperazinoethyl)propionanilides and 2-alkoxy-6-[N-[1-methyl-2-(4-phenethylpiperazino)ethyl]-propionamide]benzathiazoles

Doi:10.1248/cpb.28.3315
(1980)
Quinazolines and 1,4-benzodiazepines. XC(1). 2-aminoimidazo[1,5 a][1,4]benzodiazepin-1-ones and derivatives

Doi:10.1002/jhet.5570170810
(1980)

Article Doi