[Bis-(trifluoroacetoxy)iodo]benzene-Mediated Oxidative Direct Amination C–N Bond Formation: Synthesis of 1H-Indazoles

DOI: 10.1002/jhet.2839

Source and publish data:

Journal of Heterocyclic Chemistry p. 2426 - 2433 (2017)

Update date:2022-08-05

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Authors:

Zhang, Zhiguo

Huang, Yuanyuan

Huang, Guoqing

Zhang, Guisheng

Liu, Qingfeng

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Article abstract of DOI:10.1002/jhet.2839

An efficient [bis-(trifluoroacetoxy)iodo]benzene (PIFA)-mediated oxidative C-N bond formation is developed for the synthesis of 1H-indazoles from readily available arylhydrazones. The reaction tolerates a wide range of functional groups and has broad scope of substrates. Moreover, this method is a relative green and reliable method for rapid preparation of substituted 1H-indazoles under mild conditions.

Full text of DOI:10.1002/jhet.2839

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