Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds

DOI: 10.1021/jm00013a018

Source and publish data:

Journal of Medicinal Chemistry p. 2427 - 2432 (1995)

Update date:2022-07-29

Topics:

Authors:

Royer, Robert E.

Deck, Lorraine M.

Jagt, Timothy J. Vander

Martinez, Francella J.

Mills, Ray G.

et al. et al.

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Article abstract of DOI:10.1021/jm00013a018

1,1'-Dideoxygossypol(DDG), 1,1'-dideoxygossylic acid (DDGA), 8-deoxyhemigossypol (DHG), and 8-deoxyhemigossylic acid (DHGA) were synthesized and tested for their ability to inhibit the replication of HIV in vitro.The EC50 for DDGA was <*> 1 μM, and its th

Full text of DOI:10.1021/jm00013a018

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