Synthesis of Substituted Pyrroles by Intramolecular Condensation of a Wittig Reagent with the Carbonyl Group of a Tertiary Amide

Article abstract of DOI:10.1021/jo00325a027

1,2,5-Trisubstituted pyrroles are obtained in 50-100percent yields by addition of the conjugate bases of open-chain analogues of Reissert compounds to the vinyltriphenylphosphonium cation, with subsequent cyclization by an intramolecular Wittig reaction and base-catalyzed elimination of hydrogen cyanide.