Recueil des Travaux Chimiques des Pays-Bas p. 332 - 336 (1995)
Update date:2022-08-04
Topics:
Valentijn, A. R. P. M.
Haan, R. de
Hagens, S.
Kant, E. de
Marel, G. A. van der
et al.
A multi-step synthesis of phosphinylphosphonate analogue 12 of the proposed farnesyl-farnesyl-enzyme (FFE) intermediate in the enzymatic conversion of farnesyl pyrophosphate to squalene is described.In addition, evidence is presented of the inhibitory effect of 12 on squalene synthase.
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