1,4-Oxazines via Intramolecular Ring Closure of β-Hydroxydiazoacetamides: Phenylalanine to Tetrahydroindeno-1,4-oxazin-3(2H)-ones

Article abstract of DOI:10.1021/jo00164a009

The synthesis of the tetrahydroindeno<1,2-b>-1,4-oxazin-3(2H)-one system from phenylalanine is described.Conversion of the intermediate vicinal amino alcohol to the 1,4-oxazine was accomplished via BF3*Et2O-catalyzed ring closure of a β-hydroxydiazoacetam