TANDEM-CONJUGATE ADDITION-α-ADDITION OF UNSATURATED AMIDES. SYNTHETIC METHODOLOGY.

Article abstract of DOI:10.1016/0040-4039(80)80149-3

1,4-Addition of RLi, RMgX, and (RS)2CHLi reagents to unsaturated amides 2a-c followed by α-alkylation is shown to constitute a general and efficient synthetic procedure for the formation of two C-C bonds in a single step.