Bioorganic and Medicinal Chemistry Letters p. 5693 - 5697 (2004)
Update date:2022-08-06
Topics:
Tuthill, Paul A.
Seida, Pamela R.
Barker, William
Cassel, Joel A.
Belanger, Serge
DeHaven, Robert N.
Koblish, Michael
Gottshall, Susan L.
Little, Patrick J.
DeHaven-Hudkins, Diane L.
Dolle, Roland E.
A new class of κ-opioid receptor agonists is described. The design of these agents was based upon energy minimization and structural overlay studies of the generic azepin-2-one structure 3 with the crystal structure of arylacetamide κ agonist 1, ICI 19944
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