Tetrahedron Letters p. 6437 - 6440 (1988)
Update date:2022-08-03
Topics: Synthesis Chiral Enantioselective Hydrazones Hantzsch Dihydropyridine Synthesis Experimental Metalated
Enders, Dieter
Mueller, Stephan
Demir, Ayhan S.
An efficient, overall enantioselective variant of the Hantzsch synthesis of 4-aryl-1,4-dihydropyridines 5 (ee = 84 - 98percent), important biologically active compounds (e. g. as calcium channel blockers), is described.Key step of the new procedure is the
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