ENANTIOSELECTIVE HANTZSCH DIHYDROPYRIDINE SYNTHESIS VIA METALATED CHIRAL ALKYL ACETOACETATE HYDRAZONES

DOI: 10.1016/S0040-4039(00)82366-7

Source and publish data:

Tetrahedron Letters p. 6437 - 6440 (1988)

Update date:2022-08-03

Topics: Synthesis Chiral Enantioselective Hydrazones Hantzsch Dihydropyridine Synthesis Experimental Metalated

Authors:

Enders, Dieter

Mueller, Stephan

Demir, Ayhan S.

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Article abstract of DOI:10.1016/S0040-4039(00)82366-7

An efficient, overall enantioselective variant of the Hantzsch synthesis of 4-aryl-1,4-dihydropyridines 5 (ee = 84 - 98percent), important biologically active compounds (e. g. as calcium channel blockers), is described.Key step of the new procedure is the

Full text of DOI:10.1016/S0040-4039(00)82366-7

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