New antiulcer quassinoids from Eurycoma longifolia

Article abstract of DOI:10.1016/0223-5234(91)90069-Y

A bioassay study of Pasak bumi (Eurycoma longifolia) led to the isolation of four quassinoids, pasakbumin-A (1), -B (2), -C (4), and -D (7).Both pasakbumin-A (= eurycomanone) 1 and pasakbumin-B 2 exhibited potent antiulcer activity.This prompted us to test some modified quassinoids to reveal that ailanthone (8), the main quassinoid of Ailanthus altissima, and its α-epoxide (9) have potent activity and less toxicity.Thus, quassinoids which are generally recognised as antitumor compounds were revealed to have antiulcer activity.