Journal of the Chemical Society. Perkin transactions I p. 1068 - 1070 (1981)
Update date:2022-08-02
Topics:
Banks, Ronald E.
Brown, Alan K.
Haszeldine, Robert N.
Jefferson, John
Treatment of the methyl ethers MeOX (X = Me, Ph) with a stoicheiometric amount of bistrifluoromethyl nitroxide <(CF3)2NO. = R.> at room temperature converts them efficiently into their bistrifluoromethylamino-oxymethyl counterparts, RCH2OX; the bis-derivative (RCH2)2O is a minor by-product in the case of dimethyl ether (X = Me).Multiple hydrogen-abstraction increases in importance with diethyl ether as substrate, the expected products RCHMeOEt and (RCHMe)2O being accompanied by a bis-derivative (RCH2CHROEt) arguably produced via the αβ-dehydrogenation 2R. + Et2O -> 2RH + CH2=CHOEt.The halogeno-ether MeOCF2CHFCl reacts slowly with the nitroxide at 50 deg C to yield a 7 : 1 mixture of the derivatives RCH2OCF2CHFCl and RCFClCF2OMe, hydrolysis of which gives the esters RCH2OCOCHFCl and RCFClCO2Me, respectively.The latter ester is best obtained via treatment of methyl chlorofluoroacetate with bistrifluoromethyl nitroxide.
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