Journal of the Chemical Society. Perkin transactions I p. 1068 - 1070 (1981)
Update date:2022-08-02
Topics:
Banks, Ronald E.
Brown, Alan K.
Haszeldine, Robert N.
Jefferson, John
Treatment of the methyl ethers MeOX (X = Me, Ph) with a stoicheiometric amount of bistrifluoromethyl nitroxide <(CF3)2NO. = R.> at room temperature converts them efficiently into their bistrifluoromethylamino-oxymethyl counterparts, RCH2OX; the bis-derivative (RCH2)2O is a minor by-product in the case of dimethyl ether (X = Me).Multiple hydrogen-abstraction increases in importance with diethyl ether as substrate, the expected products RCHMeOEt and (RCHMe)2O being accompanied by a bis-derivative (RCH2CHROEt) arguably produced via the αβ-dehydrogenation 2R. + Et2O -> 2RH + CH2=CHOEt.The halogeno-ether MeOCF2CHFCl reacts slowly with the nitroxide at 50 deg C to yield a 7 : 1 mixture of the derivatives RCH2OCF2CHFCl and RCFClCF2OMe, hydrolysis of which gives the esters RCH2OCOCHFCl and RCFClCO2Me, respectively.The latter ester is best obtained via treatment of methyl chlorofluoroacetate with bistrifluoromethyl nitroxide.
View MoreSINO Industries Company Limited(expird)
Contact:86-29-85369724
Address:No.111, Jiefang Road, Xi’an, China
Contact:0792-8228321
Address:10TH Floor No.121 binjiang Road Xunyang District
Chongqing KonAo Health Co.,Ltd
Contact:13687578375
Address:wuhan hubei china
Changsha Nutritopper Bio Technology Co.,Ltd.
Contact:+86-731-87803543
Address:East 1st Street, Baima Road, Ningxiang County
Jinan Decheng Hemu Medical Technology Co.，Ltd.
Contact:+86-531-68650525
Address:NO.554 Zhengfeng Road High-new Technology Development Zone
Doi:10.1021/jo101699r
(2011)Doi:10.1134/S1070363217090237
(2017)Doi:10.1021/j100372a077
(1990)Doi:10.1002/adsc.201000547
(2010)Doi:10.1016/j.bmcl.2010.10.017
(2010)Doi:10.1039/c2ob25372k
(2012)
