Un nouvel exemple de nucleoside a sucre ramifie insature: la desoxy-3'-methylidene-3'-adenosine

DOI: 10.1002/hlca.19810640207

Source and publish data:

Helvetica Chimica Acta p. 425 - 429 (1981)

Update date:2022-08-04

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Authors:

Tronchet, Jean M. J.

Tronchet, Jeannine F.

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Article abstract of DOI:10.1002/hlca.19810640207

Starting from 5-O-benzoyl-3-C-methylidene-3-deoxy-1,2-O-isopropylidene-α-D-erythro-pentofuranose (11) the title compound 8 has been prepared.Its α-anomer (9) and the acyclic sugar nucleoside 10 have been obtained as by-products.Adenosine deaminase slowly deaminated 8, 9 being not affected.Compound 8 exhibited no antiviral activity, whereas one of its saturated analogues (13) inhibited the multiplication of the herpes-1 (HF) virus.

Full text of DOI:10.1002/hlca.19810640207

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