First aromatic electrophilic iodination reaction on the solid-phase: Iodination of bioactive peptides

Article abstract of DOI:10.1016/S0040-4039(98)01604-9

Direct iodination of Tyr residues of peptides anchored on solid supports was accomplished, for the first time, by aromatic electrophilic attack of iodonium ions provided by the IPy₂BF₄ reagent. Compatibility studies of the iodination with routine solid-phase synthesis protocols are reported.