Journal of the Chemical Society. Perkin transactions I p. 1352 - 1356 (1981)
Update date:2022-08-03
Topics:
Chien, Millie M.
Rosazza, John P.
Microbial transformations were conducted with the quassinoid bruceantin (1).Screening studies with 193 micro-organisms provided several streptomycetes capable of accumulating bruceantin metabolites.Streptomyces griseus (ATCC 10137) totally metabolized bruceantin within 19 h, and a preparative-scale incubation using bruceantin provided bruceine C (4), bruceantin 4',5'-epoxide (3), and bruceantin-5'-ol (5).Structures of metabolites were assigned based on their 1H n.m.r. and mass spectral characteristics.Metabolites (3) and (5) are novel analogues of bruceantin, and are formed by an unusual pathway involving oxidation of bruceantin, probably through the unisolated 4',5'-bruceantin olefin (2) to the epoxide (3), which serves as an obligatory precursor for bruceine C (4) and bruceantin-5'-ol (5).
View MoreWuhan Shangrisyn chemicals Technology Co.,Ltd(expird)
Contact:+86-027-84466317 __ +86-15387123698
Address:wuhan - china
Contact:+1-973-357-0577
Address:10 Taft Rd.
Changzhou Jiana Chemical Co.,Ltd
website:http://www.jianachem.com
Contact:86-0519-88731808
Address:Zhenglu Town Wujin City, Jiangsu Province
Taizhou Chenyi chemical co. LTD,
Contact:13736652831
Address:NO.273 SHANGHAI SOUTH STREET,LUQIAO DISTRICT,ZHEJIANG PROVINCE,CHINA.
Nantong Kaixin Pharma Chemical Co.,Ltd.
Contact:86-513-85250786
Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Doi:10.1246/bcsj.55.2147
(1982)Doi:10.1039/c5ra23058f
(2016)Doi:10.1055/s-1981-29424
(1981)Doi:10.1016/S0040-4039(00)00335-X
(2000)Doi:10.1002/adsc.201300846
(2013)Doi:10.1021/ja962736v
(1996)
