Synthesis of Thyrotropin-Releasing Hormone Analogues. 1. Complete Dissociation of Central Nervous Effects from Thyrotropin-Releasing Activity

DOI: 10.1021/jm00372a006

Source and publish data:

Journal of Medicinal Chemistry p. 741 - 745 (1984)

Update date:2022-08-05

Topics: Synthesis Analogues Activity Experimental

Authors:

Szirtes, Tamas

Kisfaludy, Lajos

Palosi, Eva

Szporny, Laszlo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00372a006

Twenty-four thyrotropin-releasing hormone (TRH) analogues containing mainly aliphatic amino acids in position 2 were synthesized and tested for central nervous system (CNS) and hormonal (TSH) activity.Application of the pentafluorophenyl ester method in t

Full text of DOI:10.1021/jm00372a006

Products guided by the article

Product name:Z-pGlu-Leu-pyrrolidide

Cas No:78664-60-5

R&D Labs maybe for 78664-60-5

Jintan Jinnuo Chemical Co., Ltd.

Contact:+86-519-80199901

Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Compro Shijiazhuang Fine Chemical Co., Ltd

Contact:0086-311-89689838

Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Suzhou Zhonghelong Chemical Tech Co., Ltd【License cancellation】

Contact:+86 571-12345678

Address:Dunhuang Road, Suzhou Industrial Park, No.128 building 701 room Mansion
Weifang Arylchem Chemical Co., LTD

Contact:86-536-5217866

Address:Development Zone, Shouguang, Shandong Province
Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning

Relevant to this article

Doi:10.1021/ja00404a035
(1981)
Regioselective Formation of Peroxyquinolatocobalt(III) Complexes in the Oxygenation of 2,6-DI-t-butylphenols Schiff-base Complexes

Doi:10.1039/DT9810001504
(1981)
Catalytic Oxidation of Reduced Nicotinamide Adenine Dinucleotide by Graphite Electrodes Modified with Adsorbed Aromatics Containing Catechol Functionalities

Doi:10.1021/ac00236a007
(1981)
The synthesis of highly active thiophene ring-containing chromophore components for photonic polymers based on a newly designed route

Doi:10.1039/a904945b
(1999)
Synthetic applications of aminochlorocarbenes: A two-step conversion of N-methylformanilides into 3-arylamino-2-chloroindoles

Doi:10.1055/s-2002-35228
(2002)
Synthetic anthracyclinones. XVIII. Synthesis of 13-deoxo-6-deoxydaunomycinone and β₁-citromycinone

Doi:10.1002/jlac.198119811216
(1981)

Article Doi