Synthesis of Thyrotropin-Releasing Hormone Analogues. 1. Complete Dissociation of Central Nervous Effects from Thyrotropin-Releasing Activity

DOI: 10.1021/jm00372a006

Source and publish data:

Journal of Medicinal Chemistry p. 741 - 745 (1984)

Update date:2022-08-05

Topics: Synthesis Analogues Activity Experimental

Authors:

Szirtes, Tamas

Kisfaludy, Lajos

Palosi, Eva

Szporny, Laszlo

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Article abstract of DOI:10.1021/jm00372a006

Twenty-four thyrotropin-releasing hormone (TRH) analogues containing mainly aliphatic amino acids in position 2 were synthesized and tested for central nervous system (CNS) and hormonal (TSH) activity.Application of the pentafluorophenyl ester method in t

Full text of DOI:10.1021/jm00372a006

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