Cobalt-Mediated Synthesis of Propargyl Nitriles and α-Alkoxy Propargyl Nitriles

Article abstract of DOI:10.1055/s-1989-27287

Dicobalt hexacarbonyl complexes of propargyl acetates and acetylenic acetals couple efficiently with diethylaluminum cyanide to produce the corresponding complexed propargyl nitriles and cyanohydrin derivatives, respectively.A convenient procedure for preparing propargyl nitriles and α-alkoxy propargyl nitriles from propargyl alcohols and acetylenic acetals using this methodology is described.