Journal of Medicinal Chemistry p. 1360 - 1364 (1981)
Update date:2022-08-05
Topics:
Heeres, J.
Cutsem, J. Van
The synthesis of 1-<<2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl>methyl>-1H-imidazoles is described starting with phenylacetyl bromides or 1-(phenylacetyl)imidazoles.The compounds were generally obtained as cis/trans mixtures and found to be active in vitro against dermatophytes, yeasts, other fungi, and Gram-positive bacteria.Some also showed good activity against Candida albicans in vivo.
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Doi:10.1021/jo00339a017
(1981)Doi:10.1039/jr9480001907
(1948)Doi:10.1016/S0040-4039(01)81806-2
(1981)Doi:10.1039/DT9810001572
(1981)Doi:10.1039/c3ce41805g
(2014)Doi:10.1016/j.bmc.2009.04.013
(2009)
