Antimycotic Imidazoles. 5. Synthesis and Antimycotic Properties of 1-methyl>-1H-imidazoles

DOI: 10.1021/jm00143a019

Source and publish data:

Journal of Medicinal Chemistry p. 1360 - 1364 (1981)

Update date:2022-08-05

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Authors:

Heeres, J.

Cutsem, J. Van

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Article abstract of DOI:10.1021/jm00143a019

The synthesis of 1-<<2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl>methyl>-1H-imidazoles is described starting with phenylacetyl bromides or 1-(phenylacetyl)imidazoles.The compounds were generally obtained as cis/trans mixtures and found to be active in vitro against dermatophytes, yeasts, other fungi, and Gram-positive bacteria.Some also showed good activity against Candida albicans in vivo.

Full text of DOI:10.1021/jm00143a019

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