Thiol-based SAHA analogues as potent histone deacetylase inhibitors

DOI: 10.1016/j.bmcl.2004.03.063

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Bioorganic and Medicinal Chemistry Letters p. 3313 - 3317 (2004)

Update date:2022-08-04

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Authors:

Suzuki, Takayoshi

Kouketsu, Akiyasu

Matsuura, Azusa

Kohara, Arihiro

Ninomiya, Shin-Ichi

Kohda, Kohfuku

Miyata, Naoki

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Article abstract of DOI:10.1016/j.bmcl.2004.03.063

In order to find novel nonhydroxamate histone deacetylase (HDAC) inhibitors, a series of thiol-based compounds modeled after suberoylanilide hydroxamic acid (SAHA) was synthesized, and their inhibitory effect on HDACs was evaluated. Compound 6, in which t

Full text of DOI:10.1016/j.bmcl.2004.03.063

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