Hypervalent iodine in organic synthesis: One pot facile syntheses of α-thiocyanatoacetophenones, 2-hydroxy-, and 2-mercapto-4-arylthiazoles using [hydroxy (tosyloxy)iodo]benzene

Article abstract of DOI:10.1080/00397919308011236

Hypervalent iodine oxidation of acetophenones (1a-1e) with [hydroxy(tosyloxy)iodo]benze, followed by treatment with potassium thiocyanate offers a new facile synthesis of corresponding α-thiocyanatoacetophenones (3a-3e). Cyclization of 3a-3e, thus generated in situ, using AcOH/H₂O and H₂NC(S)NH₂/HCl provides one pot facile syntheses of 2-hydroxy-, and 2-mercapto-4-arylthiazoles (4 and 5) respectively.

Full text of DOI:10.1080/00397919308011236

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Synthetic Communications: An
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Hypervalent Iodine in
Organic Synthesis: One
Pot Facile Syntheses of α-
Thiocyanatoacetophenones,
2-Hydroxy-, and 2-
Mercapto-4-arylthiazoles Using
[Hydroxy(tosyloxy)iodo]benzene
Om Prakash a & Neena Saini a
a Department of Chemistry, Kurukshetra University,
Kurukshetra, 132119, India
Published online: 23 Sep 2006.
To cite this article: Om Prakash & Neena Saini (1993) Hypervalent Iodine in Organic
Synthesis: One Pot Facile Syntheses of α-Thiocyanatoacetophenones, 2-Hydroxy-,
and 2-Mercapto-4-arylthiazoles Using [Hydroxy(tosyloxy)iodo]benzene, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 23:10, 1455-1462, DOI: 10.1080/00397919308011236
To link to this article: http://dx.doi.org/10.1080/00397919308011236
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