Journal of the American Chemical Society p. 6373 - 6377 (1981)
Update date:2022-08-04
Topics:
Gisin, B.F.
Davis, D.G.
Borowska, Z.K.
Hall, J.E.
Kobayashi, S.
Alamethicin (ALA), a natural membrane-active antibiotic, consists of several components.The major component, ALA I, was isolated in pure form and compared with the synthetic peptide acetyl-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phol obtained by stepwise segment condensation on a polystyrene support.The synthetic and natural products appeared essentially identical by amino acid analysis, high performance liquid chromatography, 600-MHz proton nuclear magnetic resonance spectroscopy, mass spectrometry, electrical activity in lipid bilayer membranes, and antimicrobial activity.It is concluded that ALA I has the structure indicated above.
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